Transcription factors and 3D genome conformation in cell-fate decisions
How cells adopt different identities has long fascinated biologists. Signal transduction in
response to environmental cues results in the activation of transcription factors that …
response to environmental cues results in the activation of transcription factors that …
Emerging roles of nuclear bodies in genome spatial organization
Nuclear bodies (NBs) are biomolecular condensates that participate in various cellular
processes and respond to cellular stimuli in the nucleus. The assembly and function of these …
processes and respond to cellular stimuli in the nucleus. The assembly and function of these …
Parp1 promotes sleep, which enhances DNA repair in neurons
The characteristics of the sleep drivers and the mechanisms through which sleep relieves
the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA …
the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA …
Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons
Sleep is essential to all animals with a nervous system. Nevertheless, the core cellular
function of sleep is unknown, and there is no conserved molecular marker to define sleep …
function of sleep is unknown, and there is no conserved molecular marker to define sleep …
Mesoscale phase separation of chromatin in the nucleus
Many measurements of chromatin packing in the nucleus of fixed cells indicate that a large
fraction of the nuclear volume is filled with chromatin. Our measurements of the spatial …
fraction of the nuclear volume is filled with chromatin. Our measurements of the spatial …
Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system
A Pourmorady, S Lomvardas - Current Opinion in Genetics & Development, 2022 - Elsevier
The mammalian genome possesses> 2000 olfactory receptor (OR) alleles regulated by 63
known OR-Enhancer elements, yet each olfactory sensory neuron (OSN) expresses only a …
known OR-Enhancer elements, yet each olfactory sensory neuron (OSN) expresses only a …
Plant 3D genomics: the exploration and application of chromatin organization
Eukaryotic genomes are highly folded for packing into higher‐order chromatin structures in
the nucleus. With the emergence of state‐of‐the‐art chromosome conformation capture …
the nucleus. With the emergence of state‐of‐the‐art chromosome conformation capture …
Nuclear mechanotransduction: sensing the force from within
A Athirasala, N Hirsch, A Buxboim - Current opinion in cell biology, 2017 - Elsevier
Highlights•Despite lacking a direct extracellular attachment, the cell nucleus is a potent
mechanotransducer.•The A-type nuclear lamina scales with extracellular stiffness and …
mechanotransducer.•The A-type nuclear lamina scales with extracellular stiffness and …
Fractal folding and medium viscoelasticity contribute jointly to chromosome dynamics
Chromosomes are key players of cell physiology, their dynamics provides valuable
information about its physical organization. In both prokaryotes and eukaryotes, the short …
information about its physical organization. In both prokaryotes and eukaryotes, the short …
Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters
Background The association of active transcription regulatory elements (TREs) with DNAse I
hypersensitivity (DHS [+]) and an 'open'local chromatin configuration has long been known …
hypersensitivity (DHS [+]) and an 'open'local chromatin configuration has long been known …