The expanding universe of PARP1-mediated molecular and therapeutic mechanisms
D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation
J O'Sullivan, M Tedim Ferreira, JP Gagné… - Nature …, 2019 - nature.com
Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …
Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer
Recent studies have pointed to PARP1 trapping as a key determinant of the anticancer
effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 …
effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 …
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
It is being increasingly appreciated that the immunomodulatory functions of PARP1
inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi …
inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi …
Poly (ADP-ribose) glycohydrolase (PARG) vs. poly (ADP-ribose) polymerase (PARP)–function in genome maintenance and relevance of inhibitors for anti-cancer …
D Harrision, P Gravells, R Thompson… - Frontiers in molecular …, 2020 - frontiersin.org
Poly (ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition
of poly (ADP-ribose)(PAR) subunits onto themselves and other acceptor proteins. PARPs …
of poly (ADP-ribose)(PAR) subunits onto themselves and other acceptor proteins. PARPs …
Identifying poly (ADP-ribose)-binding proteins with photoaffinity-based proteomics
Post-translational modification of proteins with poly (ADP-ribose)(PAR) is an important
component of the DNA damage response. Four PAR synthesis inhibitors have recently been …
component of the DNA damage response. Four PAR synthesis inhibitors have recently been …
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination
The function of poly (ADP-ribosyl) polymerase 1 (PARP1) in myelination and remyelination
of the central nervous system (CNS) remains enigmatic. Here, we report that PARP1 is an …
of the central nervous system (CNS) remains enigmatic. Here, we report that PARP1 is an …
The multifaceted role of PARP1 in RNA biogenesis
R Eleazer… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Abstract Poly (ADP‐ribose) polymerases (PARPs) are abundant nuclear proteins that
synthesize ADP ribose polymers (pADPr) and catalyze the addition of (p) ADPr to target …
synthesize ADP ribose polymers (pADPr) and catalyze the addition of (p) ADPr to target …
Runx2 (runt-related transcription factor 2) links the DNA damage response to osteogenic reprogramming and apoptosis of vascular smooth muscle cells
AM Cobb, S Yusoff, R Hayward, S Ahmad… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: The development of ectopic vascular calcification is strongly linked with
organismal aging, which is primarily caused by the accumulation of DNA damage over time …
organismal aging, which is primarily caused by the accumulation of DNA damage over time …
ADPriboDB 2.0: an updated database of ADP-ribosylated proteins
V Ayyappan, R Wat, C Barber, CA Vivelo… - Nucleic acids …, 2021 - academic.oup.com
ADP-ribosylation is a protein modification responsible for biological processes such as DNA
repair, RNA regulation, cell cycle and biomolecular condensate formation. Dysregulation of …
repair, RNA regulation, cell cycle and biomolecular condensate formation. Dysregulation of …