Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …

Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of
several human cancers, including breast cancer (BC), as strong evidence has been found …

Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

While proteolysis-targeting chimeras (PROTACs) are showing promise for targeting
previously undruggable molecules, their application has been limited by difficulties in …

Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it
plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus …

Triple-negative breast cancer (TNBC) lacks three important receptors, ER, PR, and HER2. It
is more aggressive and more likely to relapse after treatment, thus has been identified as …

microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base
pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the …

MicroRNAs (miRNAs) are short non-coding RNAs that regulate the function of target genes
at the post-transcriptional phase. miRNAs are considered to have roles in the development …

Triple-negative breast cancer (TNBC) is the most aggressive, prevalent, and distinct subtype
of breast cancer characterized by high recurrence rates and poor clinical prognosis, devoid …