Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Over the past few decades, research on Alzheimer's disease (AD) has focused on
pathomechanisms linked to two of the major pathological hallmarks of extracellular …

Background Glaucoma, the leading cause of irreversible blindness, is a retinal
neurodegenerative disease, which results from progressive apoptotic death of retinal …

Glutamate is the most abundant neurotransmitter of the central nervous system, as the
majority of neurons use glutamate as neurotransmitter. It is also well known that this …

A prominent area of neuroscience research over the past 20 years has been the acute
modulation of neuronal synaptic activity by Ca2+-dependent release of the transmitters ATP …

Neurodegenerative disorders are characterized by excitotoxicity and neuroinflammation that
finally lead to slow neuronal degeneration and death. Although neurons are the principal …

Reciprocal interactions between cells caused by release of soluble factors are essential for
brain function. So far, little attention has been paid to interactions between neurons and glia …

Psychiatric disorders have long and dominantly been regarded to be induced by
disturbances of neuronal networks including synapses and neurotransmitters. Thus, the …

The type 5 metabotropic glutamate receptor, mGlu5, has been proposed as a potential
therapeutic target for the treatment of several neurodegenerative diseases. In preclinical …

Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary
tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial …