Antimalarial drug discovery: Progress and approaches
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …
overcome emerging drug resistance, whilst considering safety and improving dosing …
[HTML][HTML] Plasmodium falciparum resistance to artemisinin-based combination therapies
Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …
Increasing prevalence of artemisinin-resistant HRP2-negative malaria in Eritrea
S Mihreteab, L Platon, A Berhane… - … England Journal of …, 2023 - Mass Medical Soc
Background Although the clinical efficacy of antimalarial artemisinin-based combination
therapies in Africa remains high, the recent emergence of partial resistance to artemisinin in …
therapies in Africa remains high, the recent emergence of partial resistance to artemisinin in …
Evolution of partial resistance to artemisinins in malaria parasites in Uganda
MD Conrad, V Asua, S Garg… - … England Journal of …, 2023 - Mass Medical Soc
Abstract Background Partial resistance of Plasmodium falciparum to the artemisinin
component of artemisinin-based combination therapies, the most important malaria drugs …
component of artemisinin-based combination therapies, the most important malaria drugs …
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
Modeling policy interventions for slowing the spread of artemisinin-resistant pfkelch R561H mutations in Rwanda
Artemisinin combination therapies (ACTs) are highly effective at treating uncomplicated
Plasmodium falciparum malaria, but the emergence of the new pfkelch13 R561H mutation in …
Plasmodium falciparum malaria, but the emergence of the new pfkelch13 R561H mutation in …
Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa
PJ Rosenthal, V Asua, MD Conrad - Nature Reviews Microbiology, 2024 - nature.com
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …
important infectious diseases in the world. Standard treatment for uncomplicated P …
Artemisinin-resistant malaria
NJ White, K Chotivanich - Clinical Microbiology Reviews, 2024 - journals.asm.org
The artemisinin antimalarials are the cornerstone of current malaria treatment. The
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …
The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular quiescence/senescence and drug resilience
J Tripathi, M Stoklasa, S Nayak, K En Low… - Nature …, 2024 - nature.com
Recrudescent infections with the human malaria parasite, Plasmodium falciparum,
presented traditionally the major setback of artemisinin-based monotherapies. Although the …
presented traditionally the major setback of artemisinin-based monotherapies. Although the …
Triple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an …
Background Late treatment failures after artemisinin-based combination therapies (ACTs) for
falciparum malaria have increased in the Greater Mekong subregion in southeast Asia …
falciparum malaria have increased in the Greater Mekong subregion in southeast Asia …