The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics

E Pajarillo, A Rizor, J Lee, M Aschner, E Lee - Neuropharmacology, 2019 - Elsevier
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

Function of alternative splicing

O Kelemen, P Convertini, Z Zhang, Y Wen, M Shen… - Gene, 2013 - Elsevier
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Transporters for L‐glutamate: An update on their molecular pharmacology and pathological involvement

PM Beart, RD O'Shea - British journal of pharmacology, 2007 - Wiley Online Library
l‐Glutamate (Glu) is the major excitatory neurotransmitter in the mammalian CNS and five
types of high‐affinity Glu transporters (EAAT1–5) have been identified. The transporters …

The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders

SM O'Donovan, CR Sullivan, RE McCullumsmith - npj Schizophrenia, 2017 - nature.com
Altered glutamate transporter expression is a common feature of many neuropsychiatric
conditions, including schizophrenia. Excitatory amino acid transporters (EAATs) are …

Neurotransmitter transporters: molecular function of important drug targets

U Gether, PH Andersen, OM Larsson… - Trends in …, 2006 - cell.com
The concentration of neurotransmitters in the extracellular space is tightly controlled by
distinct classes of membrane transport proteins. This review focuses on the molecular …

Glutamate–glutamine cycling in Alzheimer's disease

HS Walton, PR Dodd - Neurochemistry international, 2007 - Elsevier
In addition to its definitive pathological characteristics, neuritic plaques and neurofibrillary
tangles, Alzheimer's disease (AD) brain exhibits regionally variable neuronal loss and …

Molecular and cellular physiology of sodium-dependent glutamate transporters

CR Rose, D Ziemens, V Untiet, C Fahlke - Brain research bulletin, 2018 - Elsevier
Glutamate is the major excitatory transmitter in the vertebrate brain. After its release from
presynaptic nerve terminals, it is rapidly taken up by high-affinity sodium-dependent plasma …

[HTML][HTML] Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders

GM Parkin, M Udawela, A Gibbons… - World journal of …, 2018 - ncbi.nlm.nih.gov
Glutamate is the predominant excitatory neurotransmitter in the human brain and it has been
shown that prolonged activation of the glutamatergic system leads to nerve damage and cell …

Regulation and dysregulation of glutamate transporters

R Sattler, JD Rothstein - Neurotransmitter Transporters, 2006 - Springer
Glutamate is the primary excitatory neurotransmitter in the central nervous system. During
synaptic activity, glutamate is released into the synaptic cleft and binds to glutamate …

Glutamate transporters: Critical components of glutamatergic transmission

AG Rodríguez-Campuzano, A Ortega - Neuropharmacology, 2021 - Elsevier
Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system.
Once released, it binds to specific membrane receptors and transporters activating a wide …