RNAs are remarkably versatile molecules that can fold into intricate three-dimensional (3D)
structures to perform diverse cellular and viral functions. Despite their biological importance …

RNAs exhibit a plethora of functions far beyond transmitting genetic information. Often, RNA
functions are entailed in their structure, be it as a regulatory switch, protein binding site, or …

The growing recognition of the functional and therapeutic roles played by RNA and the
difficulties in gaining atomic-level insights by experiments are paving the way for all-atom …

Disordered homopolymeric regions of single-stranded RNA, such as U or A tracts, are found
within functional RNAs where they play distinct roles in defining molecular structure and …

Conformational dynamics play essential roles in RNA function. However, detailed structural
characterization of excited states of RNA remains challenging. Here, we apply high …

RNA kissing complexes are essential for genomic RNA dimerization and regulation of gene
expression, and their structures and stability are critical to their biological functions. In this …

The biological functions of RNA range from gene regulation through catalysis and depend
critically on its structure and flexibility. Conformational variations of flexible, non-base-paired …

Macromolecular structures can be determined from solution X-ray scattering. Small-angle X-
ray scattering (SAXS) provides global structural information on length scales of 10s to 100s …

Identification and characterization of base-multiplets, which are essentially mediated by
base-pairing interactions, can provide insights into the diversity in the structure and …

The structural variation of RNA is often very transient and can be easily missed in
experiments. Molecular dynamics simulation studies along with network analysis can be an …