Lysosomal storage disorders (LSDs)—designated as' orphan'diseases—are inborn errors of
metabolism caused by defects in genes that encode proteins involved in various aspects of …

Misfolding, aggregation, and aberrant accumulation of proteins are central components in
the progression of neurodegenerative disease. Cellular molecular chaperone systems …

Many neurodegenerative disorders are characterized by conformational changes in proteins
that result in misfolding, aggregation and intra-or extra-neuronal accumulation of amyloid …

Patients with type 2 diabetes have reduced gene expression of heat shock protein (HSP) 72,
which correlates with reduced insulin sensitivity. Heat therapy, which activates HSP72 …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, amyotrophic lateral sclerosis and prion-based neurodegeneration are …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which
motoneurons of the spinal cord and motor cortex die, resulting in progressive paralysis,. This …

The disruption of protein folding quality control results in the accumulation of a non-native
protein species that can form oligomers, aggregates, and inclusions indicative of …

Heat shock proteins (Hsp) form the most ancient defense system in all living organisms on
earth. These proteins act as molecular chaperones by helping in the refolding of misfolded …

Abstract Niemann-Pick type C (NPC) disease is a lysosomal storage disease (LSD)
characterized by the buildup of endo-lysosomal cholesterol and glycosphingolipids due to …

Heat shock proteins (HSPs) are induced in response to many injuries including stroke,
neurodegenerative disease, epilepsy, and trauma. The overexpression of one HSP in …