Background Melatonin prescriptions for children and adolescents have increased
substantially during the last decade. Existing clinical recommendations focus on melatonin …

Neurodegenerative diseases (NDDs) significantly contribute to morbidity and mortality
worldwide. The suboptimal effect of currently used therapeutic approaches administered via …

Melatonin has gained growing interest as a treatment of insomnia, despite contradictory
findings, and a low level of evidence. A systematic review and meta‐analysis was conducted …

Background Insomnia is the most reported sleep disorder in industrialized countries,
affecting, in the chronic form, around 10% of the European population. In Italy, such a …

Background: Glycemic variability in patients with type 2 diabetes mellitus (T2DM) may be
associated with chronic complications of the disease. Melatonin is a hormone that plays a …

Circadian rhythms are involved in the regulation of many aspects of the body, including cell
function, physical activity and disease. Circadian disturbance often predates the typical …

Traumatic brain injury (TBI) is one of the most prevalent causes of morbidity in the United
States and is associated with numerous chronic sequelae long after the point of injury. One …

Objective. Only a few studies assessing the sleep effects of low doses of melatonin (aMT)
have been performed in the past, most of them in adults, and only one in subjects with …

Abstract Study Objectives To evaluate the efficacy and safety of Dimdazenil, a novel partial
positive allosteric modulator for GABAA receptor in adults with insomnia disorder. Methods …

There is growing evidence on the importance of sleep for productivity, but little is known
about the impact of interventions targeting sleep. In a field experiment among US university …