Gene therapy is at the cusp of a revolution for treating a large spectrum of CNS disorders by
providing a durable therapeutic protein via a single administration. Adeno-associated virus …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, yet
disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) …

Many neuropathological and experimental studies suggest that the degeneration of
dopaminergic terminals and axons precedes the demise of dopaminergic neurons in the …

The identification of the most efficient method for whole central nervous system targeting that
is translatable to humans and the safest route of adeno-associated virus (AAV) …

Cytoskeleton defects, including alterations in microtubule stability, in axonal transport as
well as in actin dynamics, have been characterized in several unrelated neurodegenerative …

Neurons depend on mitochondrial functions for membrane excitability, neurotransmission,
and plasticity. Mitochondrial dynamics are important for neural cell maintenance. To …

Parkinson's disease (PD) is a complex and widespread neurodegenerative disease
characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the …

Automated gait assessment tests are used in studies of disorders characterized by gait
impairment. CatWalk XT is one of the first commercially available automated systems for …

Neurodegenerative diseases are characterized by the progressive degeneration of neurons
in the central and peripheral nervous system (CNS, PNS), resulting in a reduced innervation …