Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

The gut microbiota is a central regulator of host metabolism. The composition and function of
the gut microbiota is dynamic and affected by diet properties such as the amount and …

Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

Humans with metabolic and inflammatory diseases frequently harbour lower levels of
butyrate-producing bacteria in their gut. However, it is not known whether variation in the …

Infections have been linked to the development of cardiovascular disease and
atherosclerosis. Findings from the past decade have identified microbial ecosystems …

Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial
infarction primarily affecting women. It is not known to what extent SCAD is genetically …

Background: Chronic activation of the innate immune system drives inflammation and
contributes directly to atherosclerosis. We previously showed that macrophages in the …

Adult mammalian cardiomyocyte regeneration after injury is thought to be minimal.
Mononuclear diploid cardiomyocytes (MNDCMs), a relatively small subpopulation in the …

The microbes and microbial pathways that influence host inflammatory disease progression
remain largely undefined. Here, we show that variation in atherosclerosis burden is partially …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …