Preeclampsia is defined as new-onset hypertension after the 20th wk of gestation along with
evidence of maternal organ failure. Rates of preeclampsia have steadily increased over the …

Fetal growth restriction and related placental pathologies such as preeclampsia, stillbirth,
and placental abruption are believed to arise in early pregnancy when inadequate …

Background Severe early-onset fetal growth restriction can lead to a range of adverse
outcomes including fetal or neonatal death, neurodisability, and lifelong risks to the health of …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Preeclampsia is a common pregnancy complication, affecting 2% to 8% of pregnancies
worldwide, and is an important cause of both maternal and fetal morbidity and mortality …

It is now recognized that the quality of the fetal environment during early development is
important in programming cardiovascular health and disease in later life. Fetal hypoxia is …

Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound
sensitivity to vasopressors, such as angiotensin II, and is associated with substantial …

The availability of therapeutics to treat pregnancy complications is severely lacking mainly
because of the risk of causing harm to the fetus. As enhancement of placental growth and …

Objective To assess the effect of maternal sildenafil therapy on fetal growth in pregnancies
with early‐onset fetal growth restriction. Design A randomised placebo‐controlled trial …

Sildenafil is a new approach to treat fetal growth restriction (FGR) and preeclampsia. We
performed a systematic meta-analysis to evaluate effects of sildenafil. Our search identified …