Nitroxides, also known as nitroxyl radicals, are long-lived or stable radicals with the general
structure R1R2N–O•. The spin distribution over the nitroxide N and O atoms contributes to …

Since the definition of the “12 Principles of Green Chemistry” more than 20 years ago,
chemists have become increasingly mindful of the need to conserve natural resources and …

Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Radical intermediates in organic chemistry lack a full octet of electrons and, thus, are
commonly said to be electron deficient. By denotation, such a statement is technically …

In the past few decades, peptide antibacterial products with unique antibacterial
mechanisms have attracted widespread interest. They can effectively reduce the probability …

Since its discovery more than a century ago, the Friedel–Crafts reaction has manifested itself
as a powerful method for the introduction of carbon substituents to arenes. Despite its …

Conspectus Axially chiral compounds with rotationally constrained σ-bonds that exhibit
atropisomerism are lucrative synthetic targets because of their ubiquity in functional …

Owing to the market competitiveness and urgent societal need, an optimum speed of drug
discovery is an important criterion for successful implementation. Despite the rapid ascent of …

The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to
modern medicine's capacity to fight infectious diseases. Gram-positive species such as …

A concise, modular synthesis of the novel antibiotic darobactin A is disclosed. The synthesis
successfully forges the hallmark strained macrocyclic ring systems in a sequential fashion …