The life expectancy of the global population has increased. Aging is a natural physiological
process that poses major challenges in an increasingly long-lived and frail population …

The past 15 years have seen an explosion in our understanding of how cells replicate
damaged DNA and how this can lead to mutagenesis. The Y-family DNA polymerases lie at …

Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

Ageing is a multifactorial process associated with reduced function and increased risk of
morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have …

Base excision repair (BER) is an evolutionarily conserved process for maintaining genomic
integrity by eliminating several dozen damaged (oxidized or alkylated) or inappropriate …

The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

The structural features that enable replicative DNA polymerases to synthesize DNA rapidly
and accurately also limit their ability to copy damaged DNA. Direct replication of DNA …

Oxidative DNA damage is a major cause of cell death and mutagenesis in all aerobic
organisms, and several new oxidative base lesions have been identified in recent years …

▪ Abstract DNA repair is crucial to the well-being of all organisms from unicellular life forms to
humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the …

▪ Abstract Any living cell is faced with the fundamental task of keeping the genome intact in
order to develop in an organized manner, to function in a complex environment, to divide at …