A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health

DA Thompson, HJ Lehmler, DW Kolpin… - … Science: Processes & …, 2020 - pubs.rsc.org
Neonicotinoid insecticides are widely used in both urban and agricultural settings around
the world. Historically, neonicotinoid insecticides have been viewed as ideal replacements …

An ecotoxicological view on neurotoxicity assessment

JB Legradi, C Di Paolo, MHS Kraak… - Environmental Sciences …, 2018 - Springer
The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …

Adverse outcome pathway networks I: Development and applications

D Knapen, MM Angrish, MC Fortin… - Environmental …, 2018 - Wiley Online Library
Based on the results of a Horizon Scanning exercise sponsored by the Society of
Environmental Toxicology and Chemistry that focused on advancing the adverse outcome …

Development and analysis of an adverse outcome pathway network for human neurotoxicity

N Spinu, A Bal-Price, MTD Cronin, SJ Enoch… - Archives of …, 2019 - Springer
An adverse outcome pathway (AOP) network is an attempt to represent the complexity of
systems toxicology. This study illustrates how an AOP network can be derived and analysed …

The adverse outcome pathway: a multifaceted framework supporting 21st century toxicology

GT Ankley, SW Edwards - Current opinion in toxicology, 2018 - Elsevier
The adverse outcome pathway (AOP) framework serves as a knowledge assembly,
interpretation, and communication tool designed to support the translation of pathway …

Application of adverse outcome pathways to US EPA's endocrine disruptor screening program

P Browne, PD Noyes, WM Casey… - Environmental health …, 2017 - ehp.niehs.nih.gov
Background: The US EPA's Endocrine Disruptor Screening Program (EDSP) screens and
tests environmental chemicals for potential effects in estrogen, androgen, and thyroid …

Pollen protein and lipid content influence resilience to insecticides in honey bees (Apis mellifera)

MK Crone, CM Grozinger - Journal of Experimental Biology, 2021 - journals.biologists.com
In honey bees (Apis mellifera), there is growing evidence that the impacts of multiple
stressors can be mitigated by quality nutrition. Pollen, which is the primary source of protein …

Explicit Consideration of Temperature Improves Predictions of Toxicokinetic–Toxicodynamic Models for Flupyradifurone and Imidacloprid in Gammarus pulex

A Mangold-Döring, A Huang… - … science & technology, 2022 - ACS Publications
In the face of global climate change, where temperature fluctuations and the frequency of
extreme weather events are increasing, it is needed to evaluate the impact of temperature …

[HTML][HTML] Prioritizing chemicals of ecological concern in Great Lakes tributaries using high-throughput screening data and adverse outcome pathways

SR Corsi, LA De Cicco, DL Villeneuve… - Science of the Total …, 2019 - Elsevier
Chemical monitoring data were collected in surface waters from 57 Great Lakes tributaries
from 2010 to 13 to identify chemicals of potential biological relevance and sites at which …

[HTML][HTML] Harvesting the promise of AOPs: An assessment and recommendations

A Carusi, MR Davies, G De Grandis, BI Escher… - Science of the Total …, 2018 - Elsevier
Abstract The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and
communication tool to facilitate the transparent translation of mechanistic information into …