Abstract p70 S6 kinase (p70 S6K) is best known for its regulatory roles in protein synthesis
and cell growth by phosphorylating its primary substrate, ribosomal protein S6, upon …

The development of novel pain therapeutics hinges on the identification and rigorous
validation of potential targets. Model organisms provide a means to test the involvement of …

HuR is an RNA-binding protein implicated in RNA processing, stability, and translation.
Previously, we examined protein synthesis in dorsal root ganglion (DRG) neurons treated …

Nociceptors are a type of sensory neuron that are integral to most forms of pain. Targeted
disruption of nociceptor sensitization affords unique opportunities to prevent pain. An …

Summary mRNA translation is integral to pain, yet the key regulatory factors and their target
mRNAs are unclear. Here, we uncover a mechanism that bridges noxious insults to multiple …

RNAs are meticulously controlled by proteins. Through direct and indirect associations,
every facet in the brief life of an mRNA is subject to regulation. R NA‐b inding p roteins …

Bortezomib, an anticancer drug for multiple myeloma and mantle cell lymphoma, causes
severe adverse events and leads to peripheral neuropathy. The associated neuropathy …

Background Pain and disability are primary concerns for temporomandibular joint
osteoarthritis (TMJOA) patients, and the efficacy of current treatments remains controversial …

Sensory neurons play pervasive roles throughout biology. In vitro studies to probe their
functions hinge on the successful application of primary cell culture. Here, we present a …

Background and purpose: Translational controls pervade neurobiology. Nociceptors play an
integral role in the detection and propagation of pain signals. Nociceptors can undergo …