When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations
For most species, evolutionary adaptation is not expected to be sufficiently rapid to buffer the
effects of human‐mediated environmental changes, including environmental pollution. Here …
effects of human‐mediated environmental changes, including environmental pollution. Here …
Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters
Much structural information has been amassed on ATP-binding cassette (ABC) transporters,
including hundreds of structures of isolated domains and an increasing array of full-length …
including hundreds of structures of isolated domains and an increasing array of full-length …
Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1
The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter
that has a key role in protecting tissues from toxic insult and contributes to multidrug …
that has a key role in protecting tissues from toxic insult and contributes to multidrug …
[HTML][HTML] The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: Future …
J Goebel, J Chmielewski, CA Hrycyna - Cancer Drug Resistance, 2021 - ncbi.nlm.nih.gov
The ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp) and ABCG2 are
multidrug transporters that confer drug resistance to numerous anti-cancer therapeutics in …
multidrug transporters that confer drug resistance to numerous anti-cancer therapeutics in …
[HTML][HTML] Structure–function relationships in the human P-glycoprotein (ABCB1): insights from molecular dynamics simulations
L Mora Lagares, Y Pérez-Castillo, N Minovski… - International Journal of …, 2021 - mdpi.com
P-Glycoprotein (P-gp) is a transmembrane protein belonging to the ATP binding cassette
superfamily of transporters, and it is a xenobiotic efflux pump that limits intracellular drug …
superfamily of transporters, and it is a xenobiotic efflux pump that limits intracellular drug …
[HTML][HTML] Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers
L Braconi, S Dei, M Contino, C Riganti… - European Journal of …, 2023 - Elsevier
Abstract New 2, 5-and 1, 5-disubstituted tetrazoles, and 2, 5-disubstituted-1, 3, 4-
oxadiazoles were synthesized as tariquidar and elacridar derivatives and studied as …
oxadiazoles were synthesized as tariquidar and elacridar derivatives and studied as …
Multidrug resistance in mammals and fungi—from MDR to PDR: a rocky road from atomic structures to transport mechanisms
N Khunweeraphong, K Kuchler - International journal of molecular …, 2021 - mdpi.com
Multidrug resistance (MDR) can be a serious complication for the treatment of cancer as well
as for microbial and parasitic infections. Dysregulated overexpression of several members of …
as for microbial and parasitic infections. Dysregulated overexpression of several members of …
Homology modeling of the human P-glycoprotein (ABCB1) and insights into ligand binding through molecular docking studies
L Mora Lagares, N Minovski… - International journal of …, 2020 - mdpi.com
The ABCB1 transporter also known as P-glycoprotein (P-gp) is a transmembrane protein
belonging to the ATP binding cassette super-family of transporters; it is a xenobiotic efflux …
belonging to the ATP binding cassette super-family of transporters; it is a xenobiotic efflux …
Carbazole and polyhalogenated carbazoles in the marine environment around the Zhoushan Archipelago: Distribution characteristics, environmental behavior, and …
Z Deng, S Hu, L Tang, L Jiang, J He, K Shen… - Journal of Hazardous …, 2023 - Elsevier
The distribution characteristics and drivers of carbazole (CZ) and polyhalogenated
carbazoles are still poorly understood. In this study, 96 samples were collected around the …
carbazoles are still poorly understood. In this study, 96 samples were collected around the …
Persistent organic pollutants in fish from Charleston Harbor and tributaries, South Carolina, United States: A risk assessment
Fish consumption is an important route of exposure to persistent organic pollutants (POPs)
in dolphins as well as humans. In order to assess the potential risks associated with these …
in dolphins as well as humans. In order to assess the potential risks associated with these …