The plasma coagulation system in mammalian blood consists of a cascade of enzyme
activation events in which serine proteases activate the proteins (proenzymes and …

Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics,
display remarkable heterogeneity in structure and function. This is the first of a 2-part review …

While the blood vessel is seldom the target tissue, almost all nanomedicine will interact with
blood vessels and blood at some point of time along its life cycle in the human body …

Malaria causes an acute systemic human disease that bears many similarities, both
clinically and mechanistically, to those caused by bacteria, rickettsia, and viruses. Over the …

A significant amount of clinical and research interest in thrombosis is focused on large
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …

Human tissue factor pathway inhibitor (TFPI) is a modular protein comprised of three Kunitz
type domains flanked by peptide segments that are less structured. The sequential order of …

An inhibitor of tissue factor-induced coagulation was rediscovered in the 1980's and
subsequently named tissue factor pathway inhibitor (TFPI). Three isoforms of TFPI are …

Decreased circulating protein C and increased circulating thrombomodulin are markers of
the prothrombotic, antifibrinolytic state associated with poor outcomes in sepsis but have not …

Endothelium is strategically located at the interface between blood and interstitial tissues,
placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are …

Thrombin activatable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like proenzyme,
that after activation down regulates fibrinolysis. TAFI is activated by thrombin in the presence …