The aim of this review is to provide information for interpreting outcome results from
monitoring of antipsychotics in biological samples. A brief overview of the working …

Venlafaxine (VEN) is one of the safest and most effective drugs used in the treatment of
selective serotonin reuptake inhibitors-resistant depression, and thereby it is nowadays one …

The role of certain drug metabolizing enzymes in cardiotoxicity, such as CYP2D6 for
thioridazine, has been suggested. Risperidone has been shown to inhibit the delayed …

P-glycoprotein, a product of the ATP-binding cassette B1 (ABCB1) gene, plays an important
role in absorption and distribution of drugs. The brain entry of risperidone and 9-OH …

Antipsychotic drugs exert both therapeutic and adverse effects through dopamine D2
receptor (DRD2) antagonism. Genetic variants of this receptor may be responsible for …

In the recent years it has been increasingly recognized that pharmacogenetical factors play
an important role in the drug treatment. These factors may influence the appearance of side …

A rapid and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS)
method has been developed and validated for simultaneous quantification of risperidone …

Aim: This study aimed to determine the effect of the CYP2D6 genotype on the length of
hospitalization stay for patients treated for major depressive disorder. Methods: A total of 149 …

Bipolar disorder (BD) is a long-term illness with mood swings which are characterized by
recurrent episodes of mania/hypomania and depression, with variable interpolations of …

Among the neuroleptics, atypical antipsychotics have received great attention in recent
years, because of their peculiar pharmacological profile. Due to their widespread use, rapid …