MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs that can post-
transcriptionally regulate the expression of various oncogenes and tumor suppressor genes …

Abstract Sirtuins (SIRT1-SIRT7), a family of nicotinamide adenine dinucleotide (NAD+)-
dependent enzymes, are key regulators of life span and metabolism. In addition to acting as …

Dioscin, one natural product, has various pharmacological actions. However, its effects on
methotrexate (MTX)-induced hepatorenal damages still remain unknown. In the present …

Colorectal cancer (CRC), ranking as the third commonest cancer, leads to extremely high
rates of mortality. Metastasis is the major cause of poor outcome in CRC. When metastasis …

Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide.
Around 80% of the patients who developed advanced PCa suffered from bone metastasis …

An abnormal acyl-CoA synthetase/stearoyl-CoA desaturase (ACSL/SCD) lipid network fuels
colon cancer progression, endowing cells with invasive and migratory properties. Therapies …

Stroke is a leading cause of mortality and disability worldwide. Ischemic cell death triggered
by the compromised supply of blood oxygen and glucose is one of the major …

Sirtuins, a class III histone/protein deacetylase, is a central regulator of metabolic function
and cellular stress response. This plays a pivotal role in the pathogenesis and progression …

The mammalian urea cycle (UC) is responsible for siphoning catabolic waste nitrogen into
urea for excretion. Disruptions of the functions of any of the enzymes or transporters lead to …

Alcoholic steatohepatitis (ASH) is a progression hepatitis with severe fatty liver and its
mortality rate for 30-days in patients are over 30%. Additionally, ASH is well known for one …