Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …

Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist first developed as an
anesthetic, has shown significant promise as a medication with rapid antidepressant …

Abstract (R, S)-ketamine elicits rapid-acting and sustained antidepressant actions in
treatment-resistant patients with depression.(R)-ketamine produces longer-lasting …

Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …

Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

Ketamine treatment decreases depressive symptoms within hours, but the mechanisms
mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity …

Acute administration of (R, S)-ketamine (ketamine) produces rapid antidepressant effects
that in some patients can be sustained for several days to more than a week. Ketamine …

Ketamine is an open channel blocker of ionotropic glutamatergic N-Methyl-D-Aspartate
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …

Ketamine exhibits rapid and sustained antidepressant effects. As decreased myelination has
been linked to depression pathology, changes in myelination may be a pivotal mechanism …

Neurotrophic factors are a family of growth factors that modulate cellular growth, survival,
and differentiation. For many decades, it has been generally believed that a lack of …