Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Y Chen, X Zhao, H Zhou, H Zhu, S Jiang… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …

[PDF][PDF] Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA. 1/BA. 1.1/BA. 2/BA. 3

M Huang, L Wu, A Zheng, Y Xie, Q He, X Rong, P Han… - Immunity, 2022 - cell.com
SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies
and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal …

A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal …

H Ma, X Zhang, W Zeng, J Zhou, X Chi, S Chen… - Cell Discovery, 2022 - nature.com
Abstract Current SARS-CoV-2 Omicron subvariants impose a heavy burden on global health
systems by evading immunity from most developed neutralizing antibodies and vaccines …

Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA. 1-BA. 5

Y Wang, A Yan, D Song, C Dong, M Rao, Y Gao, R Qi… - Cell Discovery, 2023 - nature.com
SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal
antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …

The role of cyclodextrins in COVID-19 therapy—a literature review

B Almeida, C Domingues, F Mascarenhas-Melo… - International Journal of …, 2023 - mdpi.com
Coronavirus disease-19 (COVID-19) emerged in December 2019 and quickly spread, giving
rise to a pandemic crisis. Therefore, it triggered tireless efforts to identify the mechanisms of …

A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice

M Kuraoka, CB Aschner, IW Windsor… - The Journal of …, 2023 - Am Soc Clin Investig
There is an unmet need for monoclonal antibodies (mAbs) for prevention or as adjunctive
treatment of herpes simplex virus (HSV) disease. Most vaccine and mAb efforts focus on …

[PDF][PDF] Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain

Y Wang, Z Zhang, M Yang, X Xiong, Q Yan, L Cao… - Cell Reports, 2024 - cell.com
Omicron, as the emerging variant with enhanced vaccine tolerance, has sharply disrupted
most therapeutic antibodies. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection

W Tai, K Yang, Y Liu, R Li, S Feng, B Chai… - Nature …, 2023 - nature.com
The respiratory system, especially the lung, is the key site of pathological injury induced by
SARS-CoV-2 infection. Given the low feasibility of targeted delivery of antibodies into the …