Alzheimer's disease (AD), the most common chronic and progressive neurodegenerative
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …

By gating the traffic of molecules and cells across the vessel wall, endothelial cells play a
central role in regulating cardiovascular functions and systemic homeostasis and in …

Alzheimer's disease (AD) is an age-related disorder characterized by deposition of amyloid
β-peptide (Aβ) and degeneration of neurons in brain regions such as the hippocampus …

Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motor neurons in the
spinal cord resulting in progressive paralysis and death. The pathogenic mechanism of ALS …

Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be
classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols …

Programmed cell death, or apoptosis, is a complex process whereby eukaryotic cells react to
physiologic or pathophysiologic stimuli by undergoing genetically programmed suicide …

Neurodegenerative disorders are marked by extensive neuronal apoptosis and gliosis.
Although several apoptosis-inducing agents have been described, understanding of the …

The regional, cellular, and subcellular localization of phosphorylated p38 MAPK (pp38) was
examined by immunocytochemistry, immuofluorescent multiple labeling, and …

Recent data have revealed that soluble oligomeric amyloid-β peptide (Aβ) may be the
proximate effectors of neuronal injuries and death in Alzheimer's disease (AD) by unknown …

Ceramide, a tumor-suppressor lipid, is generated by sphingomyelin hydrolysis or by de novo
synthesis when cells are activated by various stress stimuli as well as when cancer cells are …