The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Cancer-associated fibroblasts (CAFs) are one of the most significant components in the
tumour microenvironment (TME), where they can perform several protumourigenic functions …

Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response
to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of …

As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is
interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in …

Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of
AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) …

Cancer‐associated fibroblasts (CAFs) have conflicting roles in the suppression and
promotion of cancer. Current research focuses on targeting the undesirable properties of …

Pancreatic ductal adenocarcinoma (PDAC) has a very poor prognosis because of its high
propensity to metastasize and its immunosuppressive microenvironment. Using a panel of …