The advent of heme during evolution allowed organisms possessing this compound to
safely and efficiently carry out a variety of chemical reactions that otherwise were difficult or …

Clinical conditions synonymous with brucellosis have been described since the time of
Hippocrates. Indeed, it has been suggested that organisms resembling brucellae have been …

We describe a comprehensive detection system for 18 kinds of classical and newly
described staphylococcal superantigenic toxin genes using four sets of multiplex PCR …

Two areas of research have recently converged to highlight important roles for Mn2+ in
pathogenesis: the recognition that both bacterial Nramp homologs and members of LraI …

We used comparative genomics to investigate the distribution of conserved DNA-binding
motifs in the regulatory regions of genes involved in iron and manganese homeostasis in …

The alpha-proteobacteria include several important genera, including the symbiotic N 2-
fixing “rhizobia” the plant pathogen Agrobacterium, the mammalian pathogens Brucella …

ABSTRACT A regulatory network of Sinorhizobium meliloti genes involved in adaptation to
iron-limiting conditions and the involvement of the rhizobial iron regulator gene (rirA) were …

The gene designated BAB1_1460 in the Brucella abortus 2308 genome sequence is
predicted to encode the manganese transporter MntH. Phenotypic analysis of an isogenic …

The Irr protein from the bacterium Bradyrhizobium japonicum is expressed under iron
limitation to mediate iron control of haem biosynthesis. The regulatory input to Irr is the status …

Abstract Background The Ferric uptake regulator (Fur) is a transcriptional regulator that
controls iron homeostasis in bacteria. Although the regulatory role of Fur in Escherichia coli …