Answer questions and earn CME/CNE Recent decades have seen an unprecedented rise in
obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than …

α-Granules are essential to normal platelet activity. These unusual secretory granules derive
their cargo from both regulated secretory and endocytotic pathways in megakaryocytes …

The biological characteristics of the tumour are used to estimate prognosis and select
appropriate systemic therapy for patients with (breast) cancer. The advent of molecular …

Vascular endothelial growth factor A (VEGF-A), the founding member of the vascular
permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with …

This critical review evaluates progress toward viable point-of-care protein biomarker
measurements for cancer detection and diagnostics. The ability to measure panels of …

The mechanisms responsible for recruiting monocytes from the bloodstream into solid
tumors are now well characterized. However, recent evidence has shown that these cells …

The measurement of circulating vascular endothelial growth factor (VEGF) levels as a
prognostic factor will gain increasing relevance in the diagnosis and evaluation of treatment …

The activation of coagulation, angiogenesis and inflammatory cytokines are considered to
be related with tumour growth and metastasis. We investigated the plasma levels of platelet …

Background Anticancer chemotherapy is thought to be effective by means of direct
cytotoxicity on tumor cells. Alternative mechanisms of efficacy have been ascribed to several …

During the 5 years since the publication of the first international consensus on the
methodology and criteria of evaluation of angiogenesis quantification in solid tumours [1] …