Metastatic tumors are often hypoxic exhibiting a decrease in extracellular pH (~ 6.5) due to a
metabolic transition described by the Warburg Effect. This shift in tumor cell metabolism …

Metalloenzymes are responsible for numerous physiological and pathological processes in
living organisms; however, there are very few FDA-approved metalloenzyme-targeting …

In the last decades, a large number of organometallic complexes have shown promising anti-
proliferative activity towards different cancer cell lines. However, these compounds generally …

The regulation of protein synthesis is vital for a host of cell biological processes, but
investigating roles for protein synthesis have been hindered by the inability to selectively …

Histone deacetylases (HDACs) are regarded as promising targets in cancer and a growing
number of other diseases due to their crucial involvement in epigenetics and cellular …

Reactive oxygen species (ROS)-activated aminoferrocene-based anticancer prodrug
candidates successfully take advantage of intrinsically high amounts of ROS in tumor …

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Patents US8684898B2 - Ionizing-radiation-responsive compositions, methods, and systems …

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Patents US8227204B2 - Ionizing-radiation-responsive compositions, methods, and systems …

Protein adsorption and dissociation on cell membrane surfaces is a topic of important study
to reveal biological processes including signal transduction and protein trafficking. We …

2008-01-25 Assigned to SEARETE LLC reassignment SEARETE LLC ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WOOD JR …