Diabetes, metabolic disease, and telomere length

F Cheng, L Carroll, MV Joglekar… - The Lancet Diabetes & …, 2021 - thelancet.com
Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …

Telomere length and oxidative stress and its relation with metabolic syndrome components in the aging

G Gavia-García, J Rosado-Pérez, TL Arista-Ugalde… - Biology, 2021 - mdpi.com
Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

B Bernardes de Jesus, E Vera… - EMBO molecular …, 2012 - embopress.org
A major goal in aging research is to improve health during aging. In the case of mice,
genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased …

The fetal programming of telomere biology hypothesis: an update

S Entringer, K de Punder, C Buss… - … Transactions of the …, 2018 - royalsocietypublishing.org
Research on mechanisms underlying fetal programming of health and disease risk has
focused primarily on processes that are specific to cell types, organs or phenotypes of …

Telomere length variations in aging and age-related diseases

S Rizvi, ST Raza, F Mahdi - Current aging science, 2014 - ingentaconnect.com
Telomeres are gene sequences present at chromosomal ends and are responsible for
maintaining genome integrity. Telomere length is maximum at birth and decreases …

[HTML][HTML] Shortened leukocyte telomere length is associated with glycemic progression in type 2 diabetes: a prospective and mendelian randomization analysis

F Cheng, AO Luk, M Shi, C Huang, G Jiang… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE Several studies support associations between relative leukocyte telomere
length (rLTL), a biomarker of biological aging and type 2 diabetes. This study investigates …

Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis

P Willeit, J Raschenberger, EE Heydon, S Tsimikas… - PloS one, 2014 - journals.plos.org
Background Short telomeres have been linked to various age-related diseases. We aimed to
assess the association of telomere length with incident type 2 diabetes mellitus (T2DM) in …

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

S Weimer, J Priebs, D Kuhlow, M Groth… - Nature …, 2014 - nature.com
Abstract d-Glucosamine (GlcN) is a freely available and commonly used dietary supplement
potentially promoting cartilage health in humans, which also acts as an inhibitor of …

Changes in regenerative capacity through lifespan

MH Yun - International journal of molecular sciences, 2015 - mdpi.com
Most organisms experience changes in regenerative abilities through their lifespan. During
aging, numerous tissues exhibit a progressive decline in homeostasis and regeneration that …

Diabetes and altered glucose metabolism with aging

RR Kalyani, JM Egan - Endocrinology and Metabolism Clinics, 2013 - endo.theclinics.com
Diabetes in older adults is a growing public health concern, with almost one-third of US
adults over the age of 60 years having diabetes, of whom approximately half are …