Next to cancer, Alzheimer's disease (AD) and dementia is probably the most worrying health
problem facing the Western world today. A large number of clinical trials have failed to show …

Background There is mounting interest in the potential efficacy of low carbohydrate and very
low carbohydrate ketogenic diets in various neurological and psychiatric disorders. Aims To …

ABSTRACT Introduction: Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are
known as principal players in different kinds of plasticity. The 5-HT–BDNF interaction in early …

Individual patients with depression present with unique symptom clusters–before, during,
and even after treatment. The prevalence of persistent, unresolved symptoms and their …

Brain function relies on efficient communications between distinct brain systems. The
pathology of major depressive disorder (MDD) damages functional brain networks, resulting …

Background Sinomenine (SIN) is an extract of the Chinese medicinal herb Sinomenium
acutum; it has various pharmacological properties, including immunosuppression and anti …

Ethnopharmacological relevance Depression induce distressed emotional state and
cognitive deficits simultaneously, which both should be improved in the treatment …

Alzheimer's disease (AD) is the main cause of dementia worldwide. Emerging non-invasive
treatments such as photobiomodulation target the mitochondria to minimize brain damage …

Drugs acting through 5-hydroxytryptamine (serotonin or 5-HT) systems modulate memory
and its alterations, although the mechanisms involved are poorly understood. 5-HT drugs …

Abstract Atractylenolide I (AT‑I), a major component of the rhizoma of Atractylodes
macrocephala Koidz., exerts a wide range of activities. The purpose of the present study was …