Triple-negative breast cancer (TNBC) cells are deficient in estrogen, progesterone and
ERBB2 receptor expression, presenting a particularly challenging therapeutic target due to …

Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Triple-negative breast cancer (TNBC) is a kind of breast cancer that lacks estrogen,
progesterone, and human epidermal growth factor receptor 2. This cancer is responsible for …

Sulfation is a dynamic and complex posttranslational modification process. It can occur at
various positions within the glycosaminoglycan (GAG) backbone and modulates …

Although altered glycosylation has been detected in human cancer cells decades ago, only
investigations in the last years have enormously increased our knowledge about the details …

Malignant transformation of cells is associated with aberrant glycosylation presented on the
cell-surface. Commonly observed changes in glycan structures during malignancy …

Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of
the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids …

Background Triple-negative breast cancer (TNBC) is a highly heterogeneous group of
cancers, and molecular subtyping is necessary to better identify molecular-based therapies …

In hormone-dependent breast cancer, estrogen receptors are the principal signaling
molecules that regulate several cell functions either by the genomic pathway acting directly …

Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …