The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem

CL Kuo, YC Lin, YK Lo, YZ Lu, AP Babuharisankar… - Iscience, 2024 - cell.com
Mitochondria play important roles in cell fate, calcium signaling, mitophagy, and the
signaling through reactive oxygen species (ROS). Recently, mitochondria are considered as …

Insights into the complexities of Citrullination: From immune regulation to autoimmune disease

J Wang, J Miao, P Zhu - Autoimmunity Reviews, 2024 - Elsevier
Citrullination, a post-translational modification that changes arginine to citrulline in proteins,
is vital for immune response modulation and cell signaling. Catalyzed by peptidyl arginine …

The Role of Citrullination Modification in CD4+ T Cells in the Pathogenesis of Immune-Related Diseases

Y Chen, Y Teng, P Xu, S Wang - Biomolecules, 2024 - mdpi.com
The post-translational modifications (PTMs) of proteins play a crucial role in increasing the
functional diversity of proteins and are associated with the pathogenesis of various …

[HTML][HTML] Peptides as Versatile Regulators in Cancer Immunotherapy: Recent Advances, Challenges, and Future Prospects

Y Lei, J Liu, Y Bai, C Zheng, D Wang - Pharmaceutics, 2025 - mdpi.com
The emergence of effective immunotherapies has revolutionized therapies for many types of
cancer. However, current immunotherapy has limited efficacy in certain patient populations …

[HTML][HTML] Vaccination with post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunity

S Shah, KW Cook, P Symonds, J Weißer… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Post-translational modification of proteins has the potential to alter the ability of
T cells to recognize major histocompatibility complex (MHC) class-I and class-II restricted …