Although current models of hippocampal function stress its well-known role in cognitive
functions, historically it has also been viewed as a neural mediator of emotion. Here, we …

Isolation-induced ultrasonic vocalizations (USVs) are emitted by young rat pups when
isolated from their dam and conspecifics. These USVs play an important role in …

Abstract Background Serotonin (5-hydroxytryptamine, 5-HT) is a key modulatory
neurotransmitter in the mammalian central nervous system (CNS) that plays an important …

Abstract Serotonin (5-hydroxytryptamine, 5-HT) is an important modulatory neurotransmitter
and functions as a key neurodevelopmental signal in the mammalian brain. 5-HT plays a …

CRF1 receptor antagonists have been proposed as novel pharmacological treatments for
depression, anxiety and stress disorders. The primary goal of the present study was to …

Although anxiety is a major feature of ethanol withdrawal (EW) and much of treatment
related to EW is focused on amelioration of the anxiety experienced during EW, less …

This study compared the effects of flibanserin, a novel 5‐HT1A agonist/5‐HT2A antagonist;
diazepam, a traditional anxiolytic; and imipramine, a traditional antidepressant, on …

Rats are highly social animals and communicate through whistle-like ultrasonic
vocalizations (USVs). Typically, three main types of USVs are distinguished based on …

Tsukuba High Emotional (THE) and Tsukuba Low Emotional (TLE) strains of rats have been
congenitally bred for use in studies of emotionality. The current study investigated THE and …

The present study investigated the effects of drugs acting on the brain nitric oxide pathway
on ultrasonic vocalizations, body temperature and locomotion in 7–8-day-old rat pups. Both …