Fluorine does not belong to the pool of chemical elements that nature uses to build organic
matter. However, chemists have exploited the unique properties of fluorine and produced …

Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Herein we report on the well-documented, yet not widely known, phenomenon of the self-
disproportionation of enantiomers (SDE): the spontaneous fractionation of scalemic material …

Alkylations of chiral or achiral Ni (II) complexes of glycine Schiff bases constitute a landmark
in the development of practical methodology for asymmetric synthesis of α-amino acids …

The major goal of this review is a critical discussion of the literature data on asymmetric
synthesis of α-amino acids via Michael addition reactions involving Ni (II)-complexes of …

The role of amino acids (AAs) in modern health industry is well-appreciated. Residues of
individual AAs, or their chemical modifications, such as diamines and amino alcohols, are …

Abstract Development of synthetic methodology for preparation of enantiomerically pure
fluorine containing amino acids (FAAs) is one of the most actively pursued areas of …

The self-disproportionation of enantiomers (SDE) is a phenomenon that can lead to the
perturbation of the enantiomeric excess (ee) in fractions obtained from a scalemic sample …

Currently, conventional reductive catalytic methodologies do not guarantee general access
to enantioenriched β-branched β-trifluoromethyl α-amino acid derivatives. Herein, a one-pot …

Over the last few years, thalidomide has become one of the most important anti-tumour
drugs for the treatment of relapsed-refractory multiple myeloma. However, besides its …