[HTML][HTML] Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products

G Kali, S Haddadzadegan, A Bernkop-Schnürch - Carbohydrate Polymers, 2024 - Elsevier
Cyclodextrins (CD) and derivatives are functional excipients that can improve the
bioavailability of numerous drugs. Because of their drug solubility improving properties they …

Cyclodextrins applied to the treatment of lysosomal storage disorders

Y Ishitsuka, T Irie, M Matsuo - Advanced Drug Delivery Reviews, 2022 - Elsevier
Cyclodextrin (CD), a cyclic oligosaccharide, is a pharmaceutical additive that improves the
solubility of hydrophobic compounds. Recent research has focused on the potential active …

Adsorption and photocatalytic removal of Rhodamine B from wastewater using carbon-based materials

TO Ajiboye, OA Oyewo, DC Onwudiwe - FlatChem, 2021 - Elsevier
The removal of Rhodamine B dyes (RhB) from wastewater, using the conventional water
treatment techniques, usually involves some challenging processes. This is challenging …

Parkinson's disease phenotypes in patient neuronal cultures and brain organoids improved by 2‐Hydroxypropyl‐β‐Cyclodextrin treatment

J Jarazo, K Barmpa, J Modamio, C Saraiva… - Movement …, 2022 - Wiley Online Library
ABSTRACT Background The etiology of Parkinson's disease (PD) is only partially
understood despite the fact that environmental causes, risk factors, and specific gene …

Cyclodextrins and iatrogenic hearing loss: new drugs with significant risk

MA Crumling, KA King, RK Duncan - Frontiers in cellular …, 2017 - frontiersin.org
Cyclodextrins are a family of cyclic oligosaccharides with widespread usage in medicine,
industry and basic sciences owing to their ability to solubilize and stabilize guest …

Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment

Y Yamada, M Fukaura‐Nishizawa… - Clinical and …, 2023 - Wiley Online Library
Abstract Background Niemann–Pick disease type C (NPC) is a fatal neurodegenerative
disorder caused by abnormal intracellular cholesterol trafficking. Cyclodextrins (CDs), the …

Inhalable dual-targeted hybrid lipid nanocore–protein shell composites for combined delivery of genistein and all-trans retinoic acid to lung cancer cells

NM Kamel, MW Helmy, EZ Abdelfattah… - ACS Biomaterials …, 2019 - ACS Publications
Localized pulmonary delivery of anticancer agents to lungs has proven to be pioneering
approach for lung cancer therapy. Hybrid lipid nanocore-protein shell nanoparticles …

2-Hydroxypropyl-β-cyclodextrins and the blood-brain barrier: Considerations for Niemann-Pick disease type C1

P Calias - Current pharmaceutical design, 2017 - ingentaconnect.com
The rare, chronic, autosomal-recessive lysosomal storage disease Niemann-Pick disease
type C1 (NPC1) is characterized by progressively debilitating and ultimately fatal …

In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C

N Yasmin, Y Ishitsuka, M Fukaura, Y Yamada… - International Journal of …, 2019 - mdpi.com
Niemann-Pick disease Type C (NPC) is a rare lysosomal storage disease characterized by
the dysfunction of intracellular cholesterol trafficking with progressive neurodegeneration …

Hydroxypropyl-β-cyclodextrin inhibits the development of triple negative breast cancer by enhancing antitumor immunity

M Zhu, Q Zhao, W Zhang, H Xu, B Zhang… - International …, 2023 - Elsevier
Triple negative breast cancer (TNBC) is regarded as one of the most aggressive forms of
breast cancer. Hydroxypropyl-β-cyclodextrin (HP-β-CD) has been used as a therapeutic …