Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …

Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

Nucleic acid sensing is a central process in the immune system, with far-reaching roles in
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …

Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
patients and experimentally infected animals indicate a critical role for augmented …

Necroptosis mediated by Z-nucleic-acid-binding protein (ZBP) 1 (also called DAI or DLM1)
contributes to innate host defense against viruses by triggering cell death to eliminate …

The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …

Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant
activation has been widely implicated in many pathologies. The pathway relies on the …

The innate immune response provides the first line of defense against infection and disease.
Regulated cell death (RCD) is a key component of innate immune activation, and RCD must …

Cell death forms an essential component of the antiviral immune response. Viral infection
elicits different forms of host cell death, including the lytic and inflammatory cell death modes …

Z-DNA Binding protein 1 (ZBP1) activates Receptor Interacting Protein Kinase 3 (RIPK3)-
dependent cell death during lytic infection by members of the orthomyxovirus, herpesvirus …