Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Genetics of diabetes mellitus and diabetes complications

JB Cole, JC Florez - Nature reviews nephrology, 2020 - nature.com
Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

A whole‐course‐repair system based on neurogenesis‐angiogenesis crosstalk and macrophage reprogramming promotes diabetic wound healing

Y Xiong, Z Lin, P Bu, T Yu, Y Endo, W Zhou… - Advanced …, 2023 - Wiley Online Library
Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to
enhance neurogenesis and angiogenesis have appeared to be a promising direction …

Multifunctional magnesium organic framework-based microneedle patch for accelerating diabetic wound healing

M Yin, J Wu, M Deng, P Wang, G Ji, M Wang, C Zhou… - Acs Nano, 2021 - ACS Publications
Diabetic wound healing is one of the major challenges in the biomedical fields. The
conventional single drug treatments have unsatisfactory efficacy, and the drug delivery …

Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation

Y Guan, H Niu, Z Liu, Y Dang, J Shen, M Zayed… - Science …, 2021 - science.org
Nonhealing diabetic wounds are common complications for diabetic patients. Because
chronic hypoxia prominently delays wound healing, sustained oxygenation to alleviate …

Role of animal models in biomedical research: a review

P Mukherjee, S Roy, D Ghosh, SK Nandi - Laboratory Animal Research, 2022 - Springer
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …

Gut microbiota and complications of type-2 diabetes

CO Iatcu, A Steen, M Covasa - Nutrients, 2021 - mdpi.com
The gut microbiota has been linked to the emergence of obesity, metabolic syndrome and
the onset of type 2 diabetes through decreased glucose tolerance and insulin resistance …

Umbilical cord-derived mesenchymal stem cell-derived exosomes combined pluronic F127 hydrogel promote chronic diabetic wound healing and complete skin …

J Yang, Z Chen, D Pan, H Li, J Shen - International journal of …, 2020 - Taylor & Francis
Purpose Chronic refractory wounds are a multifactorial comorbidity of diabetes mellitus with
the characteristic of impaired vascular networks. Currently, there is a lack of effective …

Epidemiology of peripheral neuropathy and lower extremity disease in diabetes

CW Hicks, E Selvin - Current diabetes reports, 2019 - Springer
Abstract Purpose of Review Diabetic peripheral neuropathy eventually affects nearly 50% of
adults with diabetes during their lifetime and is associated with substantial morbidity …

Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention

D Selvarajah, D Kar, K Khunti, MJ Davies… - The lancet Diabetes & …, 2019 - thelancet.com
Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and 2
diabetes. It is a leading cause of lower-limb amputation and disabling neuropathic pain …