Aging is a normal physiological process accompanied by cognitive decline. This aging
process has been the primary risk factor for development of aging-related diseases such as …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

Injury or insult to the adult nervous system often results in reactivation of signaling pathways
that are normally only active during development. The p75 neurotrophin receptor (p75 NTR) …

Sortilin is a type-1 receptor expressed in neurons of the central and peripheral nervous
systems. Initially considered a rather peculiar receptor resembling an intracellular sorting …

VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class
of type-1 receptors that are expressed in neurons. Family members are multifunctional …

Astrocytes are the main support cells of the central nervous system. They also participate in
neuroimmune reactions. In response to pathological and immune stimuli, astrocytes …

It is beyond doubt that the neurotrophin family of proteins plays key roles in determining the
fate of the neuron, not only during embryonic development, but also in the adult brain …

Alzheimer disease (AD) is a complex pathology related to multiple causes including
oxidative stress. Brain-derived neurotrophic factor (BDNF) is a neutrotrophic factor essential …

Alzheimer's disease is characterized by the accumulation of neurotoxic amyloidogenic
peptide Aβ, degeneration of the cholinergic innervation to the hippocampus (the …

Neurotrophins were christened in consideration of their actions on the nervous system and,
for a long time, they were the exclusive interest of neuroscientists. However, more recently …