Angiotensin-converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase and
is crucial in the renin-angiotensin-aldosterone system (RAAS) but also implicated in immune …

Trypanosoma cruzi, the causative agent of Chagas disease, is an obligatory intracellular
parasite with a digenetic life cycle. Due to the variety of host environments, it faces several …

The protozoan Trypanosoma cruzi triggers an inflammatory process in mammalian heart
causing events such as fibrosis, changes in the architecture and functionality in this organ …

Chagas cardiomyopathy is caused by infection with flagellated protozoan Trypanosoma
cruzi. In patients, there is a fine balance between control of the replication and the intensity …

Chagas cardiomyopathy remodeling is based on the presence of Trypanosoma cruzi in
heart tissue and on the complex inflammatory response leading to a myocardium fibrosis …

Trypanosoma cruzi infection induces progressive cardiac inflammation that leads to fibrosis
and modifications in the heart architecture and functionality. Statins, such as 3-hydroxy-3 …

We examined the effect of exercise training (Ex) without (Ex 0%) or with a 3% workload (Ex
3%) on different cardiac and renal parameters in renovascular hypertensive (2K1C) male …

Chronic chagasic myocarditis (CCM) depends on Trypanosoma cruzi persistence in the
myocardium. Studies of the proteolytic mechanisms governing host/parasite balance in …

Trypanosoma cruzi infection triggers a chronic inflammatory process responsible for the
alterations in the extracellular matrix and functionality of the heart. The angiotensin …

Objective Trypanosoma cruzi infection affects millions of people worldwide, and the drugs
available for its treatment have limited efficacy. 1, 8-Dioxooctahydroxanthenes and …