Behavior testing in rodents: highlighting potential confounds affecting variability and reproducibility

RM Saré, A Lemons, CB Smith - Brain sciences, 2021 - mdpi.com
Rodent models of brain disorders including neurodevelopmental, neuropsychiatric, and
neurodegenerative diseases are essential for increasing our understanding of underlying …

Enriched environments as a potential treatment for developmental disorders: a critical assessment

NJ Ball, E Mercado III, I Orduña - Frontiers in psychology, 2019 - frontiersin.org
The beneficial effects of enriched environments have been established through a long
history of research. Enrichment of the living conditions of captive animals in the form of …

Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice

H Yamaguchi, Y Hara, Y Ago, E Takano… - Behavioural brain …, 2017 - Elsevier
We recently demonstrated that prenatal exposure to valproic acid (VPA) at embryonic day
12.5 causes autism spectrum disorder (ASD)-like phenotypes such as hypolocomotion …

Vasopressin as possible treatment option in autism spectrum disorder

K László, D Vörös, P Correia, CL Fazekas, B Török… - Biomedicines, 2023 - mdpi.com
Autism spectrum disorder (ASD) is rather common, presenting with prevalent early problems
in social communication and accompanied by repetitive behavior. As vasopressin was …

The social component of environmental enrichment is a pro-neurogenic stimulus in adult c57BL6 female mice

EP Moreno-Jiménez, J Jurado-Arjona… - Frontiers in cell and …, 2019 - frontiersin.org
In rodents, the hippocampal dentate gyrus gives rise to newly generated dentate granule
cells (DGCs) throughout life. This process, named adult hippocampal neurogenesis (AHN) …

Early environmental enrichment for autism spectrum disorder Fmr1 mice models has positive behavioral and molecular effects

Y Chen, S Zhang, C Yue, P Xiang, J Li, Z Wei, L Xu… - Experimental …, 2022 - Elsevier
Autism spectrum disorder is a complex neurodevelopmental condition with genetic and
phenotypic heterogeneity characterized by hallmark impairments in social functioning and …

SHANK3 Mutations Associated with Autism and Schizophrenia Lead to Shared and Distinct Changes in Dendritic Spine Dynamics in the Developing Mouse Brain

C Huang, MM Voglewede, EN Ozsen, H Wang… - Neuroscience, 2023 - Elsevier
Abstract Autism Spectrum Disorders (ASD) and schizophrenia are distinct
neurodevelopmental disorders that share certain symptoms and genetic components. Both …

Shaping the development of complex social behavior

JP Curley, FA Champagne - Annals of the New York Academy …, 2023 - Wiley Online Library
Early life experiences can have an enduring impact on the brain and behavior, with
implications for stress reactivity, cognition, and social behavior. In particular, the neural …

Dual profile of environmental enrichment and autistic-like behaviors in the maternal separated model in rats

M Mansouri, H Pouretemad, G Wegener… - International Journal of …, 2021 - mdpi.com
Background: Environmental Enrichment (EE) has been suggested as a possible therapeutic
intervention for neurodevelopmental disorders such as autism. Although the benefits of this …

Interaction between the opioid receptor OPRM1 gene and mother-child language style matching prospectively predicts children's separation anxiety disorder …

S Boparai, JL Borelli, L Partington, P Smiley… - Research in …, 2018 - Elsevier
Recent research suggests that lower mother-child language style matching (LSM) is
associated with greater physiological reactivity and insecure attachment in school-aged …