Background Appropriate antibiotic (AB) therapy remains a challenge in the intensive care
unit (ICU). Procalcitonin (PCT)-guided AB stewardship could help optimize AB treatment and …

This review aims to summarize current progress in the management of critically ill, using
biomarkers as guidance for antimicrobial treatment with a focus on antimicrobial …

Background For ventilator-associated pneumonia (VAP), the safety of short-course versus
long-course antibiotic therapy is still debated, especially regarding documented VAP due to …

Introduction Considering the ongoing increase in antibiotic resistance, the importance of
judicious use of antibiotics through reduction of exposure is crucial. Adding procalcitonin …

Guidelines for the Use of Procalcitonin for Rational Use of Antibiotics - PMC Back to Top Skip
to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main …

Objectives C-reactive protein (CRP) and procalcitonin (PCT) are widely used biomarkers in
high-income countries. However, evidence for their use in low-and middle-income countries …

Background Current guidelines recommend short-duration antibiotic therapy for non-
fermenting gram-negative bacilli (NF-GNB) ventilator-associated pneumonia (VAP) which …

Immune organ failure is frequent in critical illness independent of its cause and has been
acknowledged for a long time. Most patients admitted to the ICU, whether featuring infection …

Background The impact of using biomarkers to determine the duration of antibiotics therapy
has been studied. However, the question remains in clinical practice whether these …

Introduction Sepsis is a heterogeneous syndrome often misdiagnosed. Point-of-care (POC)
diagnostic tests are commonly used to guide decision and include host biomarkers and …