In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV),
we reflect on the merits and limitations of the viral strains currently being used to develop …

Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging
to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging …

Human cytomegalovirus (HCMV) in clinical material cannot replicate efficiently in vitro until it
has adapted by mutation. Consequently, wild-type HCMV differ fundamentally from the …

Human cytomegalovirus (CMV) has infected humans since the origin of our species and
currently infects most of the world's population. Variability between CMV genomes is the …

Human cytomegalovirus is a widespread pathogen of major medical importance. It causes
significant morbidity and mortality in immunocompromised individuals, and congenital …

Research has shown that RNA virus populations are highly variable, most likely due to low
fidelity replication of RNA genomes. It is generally assumed that populations of DNA viruses …

Mutations that occurred during adaptation of human cytomegalovirus to cell culture were
monitored by isolating four strains from clinical samples, passaging them in various cell …

OBJECTIVE: To determine contribution of reinfection with new strains of cytomegalovirus in
cytomegalovirus seromimmune women to incidence of congenital cytomegalovirus infection …

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural
infection although little is known about the limits or patterns of HCMV diversity among …

The genomic characteristics of human cytomegalovirus (HCMV) strains sequenced directly
from clinical pathology samples were investigated, focusing on variation, multiple-strain …