Age-related changes in aortic biomechanics can impact the brain by reducing blood flow
and increasing pulsatile energy transmission. Clinical studies have shown that impaired …

Thoracic endovascular aortic repair (TEVAR) is a commonly performed operation for
patients with type B aortic dissection (TBAD). The goal of TEVAR is to cover the proximal …

This study investigates the physics of the longitudinal stretching-based wave pumping
mechanism, a novel extension of the traditional impedance pump. In its simplest form, an …

In-vitro models of the systemic circulation have gained a lot of interest for fundamental
understanding of cardiovascular dynamics and for applied hemodynamic research. In this …

Objective: The clinical significance of the wave intensity (WI) analysis for the diagnosis and
prognosis of the cardiovascular and cerebrovascular diseases is well-established. However …

Aortic stiffness increases with age and is a robust predictor of brain pathology including
Alzheimer's and other dementias. Aging causes disproportionate stiffening of the aorta …

The reductionist approach has dominated the fields of biology and medicine for nearly a
century. Here, we present a systems science approach to the analysis of physiological …

Recent studies showed that wave intensity analysis (WIA) provides clinically valuable
information about local and global cardiovascular function. Wave intensity (WI) is computed …

An impedance pump–also known as Liebau pump–is a simple valveless pump that operates
based on the principles of wave propagation and reflection. It has been shown in embryonic …

Abstract Aims Cardiovascular intrinsic frequencies (IFs) are associated with cardiovascular
health and disease, separately capturing the systolic and diastolic information contained in a …