Cannabinoids and the expanded endocannabinoid system in neurological disorders

L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: an update on current evidence and …

EP Baron - Headache: The Journal of Head and Face Pain, 2018 - Wiley Online Library
Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

Cannabis pharmacology: the usual suspects and a few promising leads

EB Russo, J Marcu - Advances in pharmacology, 2017 - Elsevier
The golden age of cannabis pharmacology began in the 1960s as Raphael Mechoulam and
his colleagues in Israel isolated and synthesized cannabidiol, tetrahydrocannabinol, and …

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

O Devinsky, MR Cilio, H Cross, J Fernandez‐Ruiz… - …, 2014 - Wiley Online Library
To present a summary of current scientific evidence about the cannabinoid, cannabidiol
(CBD) with regard to its relevance to epilepsy and other selected neuropsychiatric disorders …

The effects of cannabidiol, a non-intoxicating compound of cannabis, on the cardiovascular system in health and disease

A Kicman, M Toczek - International journal of molecular sciences, 2020 - mdpi.com
Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis
which exhibits potential beneficial properties in a wide range of diseases, including …

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

J Fernández‐Ruiz, O Sagredo… - British journal of …, 2013 - Wiley Online Library
Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous
disorders exerted through molecular mechanisms that are yet to be completely identified …

New horizons for newborn brain protection: enhancing endogenous neuroprotection

KJ Hassell, M Ezzati, D Alonso-Alconada… - Archives of Disease in …, 2015 - fn.bmj.com
Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors

E Martínez-Pinilla, K Varani, I Reyes-Resina… - Frontiers in …, 2017 - frontiersin.org
The mechanism of action of cannabidiol (CBD), the main non-psychotropic component of
Cannabis sativa L., is not completely understood. First assumed that the compound was …

Cannabis and adolescent brain development

DI Lubman, A Cheetham, M Yücel - Pharmacology & therapeutics, 2015 - Elsevier
Heavy cannabis use has been frequently associated with increased rates of mental illness
and cognitive impairment, particularly amongst adolescent users. However, the …

An overview on medicinal chemistry of synthetic and natural derivatives of cannabidiol

P Morales, PH Reggio, N Jagerovic - Frontiers in pharmacology, 2017 - frontiersin.org
Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however
historically, it has received far less interest as a single drug than the other components of …