Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

The eye has anatomical structures that function as robust static and dynamic barriers,
limiting the penetration, residence time, and bioavailability of medications administered …

Blindness and impaired vision are considered as the most troublesome health conditions
leading to significant socioeconomic strains. The current study focuses on development of …

This study aimed at delivering intranasal zolmitriptan directly to the brain through
preparation of bilosomes incorporated into a mucoadhesive in situ gel with extended nasal …

Introduction Niosomes have recently grabbed attention as one of the best tools for various
site-specific drug delivery systems, including ophthalmic drug delivery. Surfactants …

Glaucoma, a chronic disease of elevated intraocular pressure, is considered as the first
leading cause of blindness. Brimonidine tartrate (BRT), a hydrophilic drug with poor ocular …

Introduction: Glaucoma affects more than 70 million people worldwide. One of the major
therapeutic options for its management is based on the inhibition of the metalloenzyme …

Agomelatine (AGO) is a dual-functional drug. It uses as an antidepressant when orally
administrated and antiglaucomic when topically applied to the eye. This study aimed to …

Brimonidine tartrate (BRT) is a hydrophilic α2 adrenergic agonist used for the treatment of
glaucoma. Glaucoma is an ocular disease affecting the anterior segment of the eye requiring …

Sertaconazole nitrate (STZ) is a poorly soluble antifungal drug commonly used for treating
fungal skin infections. Introducing it as a new treatment option for the management of fungal …