Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

JY Lee, A Martin-Bastida, A Murueta-Goyena… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions

A Zarkali, GEC Thomas, H Zetterberg… - Nature …, 2024 - nature.com
A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …

The use of optical coherence tomography in neurology: a review

JS Xie, L Donaldson, E Margolin - Brain, 2022 - academic.oup.com
Optical coherence tomography is a non-invasive, cost-efficient technique that provides high-
resolution in vivo imaging of retinal tissue. The peripapillary retinal nerve fibre layer and …

Structural and functional changes in the retina in Parkinson's disease

JN Alves, BU Westner, A Højlund, RS Weil… - Journal of Neurology …, 2023 - jnnp.bmj.com
Parkinson's disease is caused by degeneration of dopaminergic neurons, originating in the
substantia nigra pars compacta and characterised by bradykinesia, rest tremor and rigidity …

Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disorders

S Diaz-Torres, W He, J Thorp, S Seddighi, S Mullany… - …, 2023 - thelancet.com
Background Primary open-angle glaucoma (POAG) is an optic neuropathy characterized by
progressive degeneration of the optic nerve that leads to irreversible visual impairment …

Visual dysfunction is a better predictor than retinal thickness for dementia in Parkinson's disease

N Hannaway, A Zarkali, LA Leyland… - Journal of Neurology …, 2023 - jnnp.bmj.com
Background Dementia is a common and devastating symptom of Parkinson's disease (PD).
Visual function and retinal structure are both emerging as potentially predictive for dementia …

Foveal remodeling of retinal microvasculature in Parkinson's disease

A Murueta-Goyena, M Barrenechea… - Frontiers in …, 2021 - frontiersin.org
Background Retinal microvascular alterations have been previously described in
Parkinson's disease (PD) patients using optical coherence tomography angiography (OCT …

Wavelet-based selection-and-recalibration network for Parkinson's disease screening in OCT images

J Huang, X Zhang, R Jin, T Xu, Z Jin, M Shen… - Computer Methods and …, 2024 - Elsevier
Abstract Background and Objective: Parkinson's disease (PD) is one of the most prevalent
neurodegenerative brain diseases worldwide. Therefore, accurate PD screening is crucial …

Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson's disease

H Zhou, B Shen, Z Huang, S Zhu, W Yang, F Xie… - npj Parkinson's …, 2023 - nature.com
Retinal thickness is related to Parkinson's disease (PD), but its association with the severity
of PD is still unclear. We conducted a Mendelian randomized (MR) study to explore the …

[HTML][HTML] Central retina thickness measured with spectral-domain optical coherence tomography in Parkinson disease: A meta-analysis

YW Lee, MN Lim, JY Lee, YJ Yoo - Medicine, 2023 - journals.lww.com
Background: Optical coherence tomography (OCT) can detect visual alterations associated
with Parkinson disease, such as damage to the retinal nerve fiber layer or changes in retinal …