Various modeling and experimental studies have analyzed the reactions, interconnections,
and motifs in two-component systems, with an eye toward understanding their physiological …

The group A streptococcus (GAS) causes a variety of human diseases, including toxic shock
syndrome and necrotizing fasciitis, which are both associated with significant mortality. Even …

Summary Group B Streptococcus (GBS) is an important cause of invasive infections in
humans. The pathogen encodes a number of virulence factors including the pluripotent β …

Signal transducing mechanisms are essential for regulation of gene expression in both
prokaryotic and eukaryotic organisms. Regulation of gene expression in eukaryotes is …

Advances in molecular technology have furthered our understanding of virulence factors that
underpin group A streptococcus invasiveness. The increased prevalence of invasive …

In this investigation, we identify the CodY protein from Streptococcus pyogenes as a
pleiotropic transcription regulator with global features. The notion that acquisition of nutrients …

All living organisms communicate with the external environment for their survival and
existence. In prokaryotes, communication is achieved by two‐component systems (TCS) …

Streptococcus mutans is an important etiological agent of dental caries in humans. The
extracellular polysaccharides synthesized by cell-associated glucosyltransferases (encoded …

Phosphorylation relays are a major mechanism by which bacteria alter transcription in
response to environmental signals, but understanding of the functional consequences of …

The CovR/S two‐component system regulates the transcription of many genes that are
crucial for the virulence of Streptococcus pyogenes (group A Streptococcus, GAS) …