Mounting evidence suggests that platelets play an essential role in cancer metastasis. The
interactions between platelets and circulating tumor cells (CTCs) promote cancer …

Cancer stem cell (CSCs) are deemed as one of the main reasons of tumor relapse due to
their resistance to standard therapies. Numerous intracellular signaling pathways along with …

Simple Summary Cutaneous squamous cell carcinoma (cSCC) is the second most common
form of skin cancer worldwide. Due to its high mutational burden, cSCC remains poorly …

Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), referred to as
keratinocyte carcinomas, are skin cancer with the highest incidence. BCCs, rarely …

The interaction of non-kinase transmembrane glycoprotein CD44 with ligands including
hyaluronic acid (HA) is closely related to the occurrence and development of tumors …

Epiretinal membranes (ERMs) are sheets of tissue that pathologically develop in the
vitreoretinal interface leading to progressive vision loss. They are formed by different cell …

Podoplanin is a sialomucin-like type I transmembrane receptor glycoprotein that is
expressed specifically in lymphatic vessels, sebaceous glands, and hair follicles in normal …

ABSTRACT In adaptive immunity, CLEC-2+ dendritic cells (DCs) contact fibroblastic reticular
cells (FRCs) inhibiting podoplanin-dependent actomyosin contractility, permitting FRC …

Background The biological functions of Hyaluronic acid are related to its molecular weight
and binding to its receptor, Toll-like receptor4 (TLR4) or CD44. Recent studies have shown …

The invasiveness of late‐stage cutaneous squamous cell carcinoma (cSCC) is associated
with poor patients' prognosis and linked to strong upregulation of the glycoprotein …