This report describes the development of an orally active analgesic that resolves
inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts …

Although chemotherapy is a conventional cancer treatment, it may induce a protumorigenic
microenvironment by triggering the release of proinflammatory mediators. In this study, we …

Polyunsaturated fatty acids (PUFAs) including epoxide-modified ω-3 and ω-6 fatty acids are
made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function …

Toxic environmental carcinogens promote cancer via genotoxic and nongenotoxic
pathways, but nongenetic mechanisms remain poorly characterized. Carcinogen-induced …

Pulmonary fibrosis (PF) is a senescence‐associated disease with poor prognosis. Currently,
there is no effective therapeutic strategy for preventing and treating the disease process …

Gastric ulcer is a common gastrointestinal ailment that affects many people worldwide.
NSAIDs induced ulcers are the second most common etiology of gastric ulcers. Coconut oil …

The dry root of Hedysarum polybotrys Hand.-Mazz., commonly known as “Hong Qi”, has a
variety of health benefits. The present study was undertaken to explore the anti-gastric ulcer …

Diabetes-induced male sexual dysfunction is associated with endothelial dysfunction.
Inhibition of soluble epoxide hydrolase (sEH) is known to improve endothelial function in …

Osteoarthritis (OA) is a degenerative joint disease that causes pain and bone deterioration
driven by an increase in prostaglandins (PGs) and inflammatory cytokines. Current …

Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) are among one of the most
commonly prescribed medications for pain and inflammation. Diclofenac (DIC) is a …