[HTML][HTML] The interaction mechanism between autophagy and apoptosis in colon cancer

Q Xie, Y Liu, X Li - Translational Oncology, 2020 - Elsevier
Autophagy and apoptosis play crucial roles in tumorigenesis. Recent studies have shown
that autophagy and apoptosis have a cross-talk relationship in anti-tumor therapy. It is well …

Elucidating role of reactive oxygen species (ROS) in cisplatin chemotherapy: a focus on molecular pathways and possible therapeutic strategies

S Mirzaei, K Hushmandi, A Zabolian, H Saleki… - Molecules, 2021 - mdpi.com
The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …

Combination of an autophagy inducer and an autophagy inhibitor: a smarter strategy emerging in cancer therapy

T Liu, J Zhang, K Li, L Deng, H Wang - Frontiers in pharmacology, 2020 - frontiersin.org
Autophagy is considered a cytoprotective function in cancer therapy under certain conditions
and is a drug resistance mechanism that represents a clinical obstacle to successful cancer …

Voltage-gated potassium channels as regulators of cell death

M Bachmann, W Li, MJ Edwards, SA Ahmad… - Frontiers in cell and …, 2020 - frontiersin.org
Ion channels allow the flux of specific ions across biological membranes, thereby
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …

The role of autophagy in gastric cancer chemoresistance: friend or foe?

JL Xu, L Yuan, YC Tang, ZY Xu, HD Xu… - Frontiers in Cell and …, 2020 - frontiersin.org
Gastric cancer is the third most common cause of cancer-related death worldwide. Drug
resistance is the main inevitable and vital factor leading to a low 5-year survival rate for …

HMGB1 in the interplay between autophagy and apoptosis in cancer

R Chen, J Zou, X Zhong, J Li, R Kang, D Tang - Cancer Letters, 2023 - Elsevier
Lysosome-mediated autophagy and caspase-dependent apoptosis are dynamic processes
that maintain cellular homeostasis, ensuring cell health and functionality. The intricate …

Challenges and therapeutic opportunities of autophagy in cancer therapy

VR Silva, SP Neves, LS Santos, RB Dias, DP Bezerra - Cancers, 2020 - mdpi.com
Simple Summary Autophagy is a physiological process characterized by the degradation of
the cell components through lysosomes due to stimuli/stress. In this study, we review the …

Ion channels and pumps in autophagy: A reciprocal relationship

H Abuammar, A Bhattacharjee, Z Simon-Vecsei… - Cells, 2021 - mdpi.com
Autophagy, the process of cellular self-degradation, is intrinsically tied to the degradative
function of the lysosome. Several diseases have been linked to lysosomal degradative …

Overcoming therapy resistance in colon cancer by drug repurposing

T El Zarif, M Yibirin, D De Oliveira-Gomes… - Cancers, 2022 - mdpi.com
Simple Summary Despite improvements in standardized screening methods and the
development of promising therapies for colorectal cancer (CRC), survival rates are still low …

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

M Li, P Tian, Q Zhao, X Ma, Y Zhang - Frontiers in Oncology, 2023 - frontiersin.org
In recent years, the role of potassium channels in tumors has been intensively studied.
Potassium channel proteins are widely involved in various physiological and pathological …