Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …

Due to its poor prognosis and the late stage at which it is typically diagnosed, early detection
of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Tumor-
derived extracellular vesicles (EVs) induce pre-metastatic niche formation to promote …

Background Pancreatic cancer has been and still is associated with a very poor prognosis.
This is due to a lack of major breakthroughs with respect to early diagnosis, prognostication …

Malignant biliary obstruction is a challenging condition, requiring a multimodal approach for
both diagnosis and treatment. Pancreatic adenocarcinoma and cholangiocarcinoma are the …

Purpose: Pancreatic cancer is a challenging malignancy with low treatment option and poor
life expectancy. Thermal ablation techniques were proposed as alternative treatment …

Introduction Approximately, 20% of patients with pancreatic ductal adenocarcinoma have
resectable disease at diagnosis. Given improvements in locoregional and systemic …

Despite the remarkable success of immunotherapy in many types of cancer, pancreatic
ductal adenocarcinoma has yet to benefit. Innate immune cells are critical to anti-tumor …

Simple Summary Pancreatic cancer remains one of the most dreaded cancers worldwide.
The incidence of this relatively rare cancer is increasing by almost 1.0% per year. It is …

Simple Summary IRS4 (insulin receptor substrate4) belongs to a family of intracellular
proteins that include IRS1 and IRS2 and whose physiological function is to transmit the …